Spike sorting is a crucial step in decoding multichannel extracellular neural signals, enabling the identification of individual neuronal activity. A key challenge in brain-machine interfaces (BMIs) is achieving real-time, low-power spike sorting at the edge while keeping high neural decoding performance. This study introduces the Neuromorphic Sparse Sorter (NSS), a compact two-layer spiking neural network optimized for efficient spike sorting. NSS leverages the Locally Competitive Algorithm (LCA) for sparse coding to extract relevant features from noisy events with reduced computational demands. NSS learns to sort detected spike waveforms in an online fashion and operates entirely unsupervised. To exploit multi-bit spike coding capabilities of neuromorphic platforms like Intel's Loihi 2, a custom neuron model was implemented, enabling flexible power-performance trade-offs via adjustable spike bit-widths. Evaluations on simulated and real-world tetrode signals with biological drift showed NSS outperformed established pipelines such as WaveClus3 and PCA+KMeans. With 2-bit graded spikes, NSS on Loihi 2 outperformed NSS implemented with leaky integrate-and-fire neuron and achieved an F1-score of 77% (+10% improvement) while consuming 8.6mW (+1.65mW) when tested on a drifting recording, with a computational processing time of 0.25ms (+60 us) per inference.

Having an LLM that aligns with human preferences is essential for accommodating individual needs, such as maintaining writing style or generating specific topics of interest. The majority of current alignment methods rely on fine-tuning or prompting, which can be either costly or difficult to control. Model steering algorithms, which modify the model output by constructing specific steering directions, are typically easy to implement and optimization-free. However, their capabilities are typically limited to steering the model into one of the two directions (i.e., bidirectional steering), and there has been no theoretical understanding to guarantee their performance. In this work, we propose a theoretical framework to understand and quantify the model steering methods. Inspired by the framework, we propose a confident direction steering method (CONFST) that steers LLMs via modifying their activations at inference time. More specifically, CONFST builds a confident direction that is closely aligned with users' preferences, and this direction is then added to the activations of the LLMs to effectively steer the model output. Our approach offers three key advantages over popular bidirectional model steering methods: 1) It is more powerful, since multiple (i.e. more than two) users' preferences can be aligned simultaneously; 2) It is simple to implement, since there is no need to determine which layer to add the steering vector to; 3) No explicit user instruction is required. We validate our method on GPT-2 XL (1.5B), Mistral (7B) and Gemma-it (9B) models for tasks that require shifting the output of LLMs across various topics and styles, achieving superior performance over competing methods.

Network tomography is a crucial problem in network monitoring, where the observable path performance metric values are used to infer the unobserved ones, making it essential for tasks such as route selection, fault diagnosis, and traffic control. However, most existing methods either assume complete knowledge of network topology and metric formulas-an unrealistic expectation in many real-world scenarios with limited observability-or rely entirely on black-box end-to-end models. To tackle this, in this paper, we argue that a good network tomography requires synergizing the knowledge from both data and appropriate inductive bias from (partial) prior knowledge. To see this, we propose Deep Network Tomography (DeepNT), a novel framework that leverages a path-centric graph neural network to predict path performance metrics without relying on predefined hand-crafted metrics, assumptions, or the real network topology. The path-centric graph neural network learns the path embedding by inferring and aggregating the embeddings of the sequence of nodes that compose this path. Training path-centric graph neural networks requires learning the neural netowrk parameters and network topology under discrete constraints induced by the observed path performance metrics, which motivates us to design a learning objective that imposes connectivity and sparsity constraints on topology and path performance triangle inequality on path performance. Extensive experiments on real-world and synthetic datasets demonstrate the superiority of DeepNT in predicting performance metrics and inferring graph topology compared to state-of-the-art methods.

Phishing has long been a common tactic used by cybercriminals and continues to pose a significant threat in today's digital world. When phishing attacks become more advanced and sophisticated, there is an increasing need for effective methods to detect and prevent them. To address the challenging problem of detecting phishing emails, researchers have developed numerous solutions, in particular those based on machine learning (ML) algorithms. In this work, we take steps to study the efficacy of large language models (LLMs) in detecting phishing emails. The experiments show that the LLM achieves a high accuracy rate at high precision; importantly, it also provides interpretable evidence for the decisions.

Understanding how molecular changes caused by genetic variation drive disease risk is crucial for deciphering disease mechanisms. However, interpreting genome sequences is challenging because of the vast size of the human genome, and because its consequences manifest across a wide range of cells, tissues and scales -- spanning from molecular to whole organism level. Here, we present Phenformer, a multi-scale genetic language model that learns to generate mechanistic hypotheses as to how differences in genome sequence lead to disease-relevant changes in expression across cell types and tissues directly from DNA sequences of up to 88 million base pairs. Using whole genome sequencing data from more than 150 000 individuals, we show that Phenformer generates mechanistic hypotheses about disease-relevant cell and tissue types that match literature better than existing state-of-the-art methods, while using only sequence data. Furthermore, disease risk predictors enriched by Phenformer show improved prediction performance and generalisation to diverse populations. Accurate multi-megabase scale interpretation of whole genomes without additional experimental data enables both a deeper understanding of molecular mechanisms involved in disease and improved disease risk prediction at the level of individuals.

Machine learning (ML) models frequently rely on training data that may include sensitive or personal information, raising substantial privacy concerns. Legislative frameworks such as the General Data Protection Regulation (GDPR) and the California Consumer Privacy Act (CCPA) have necessitated the development of strategies that preserve privacy while maintaining the utility of data. In this paper, we investigate the capability of Large Language Models (LLMs) to generate synthetic datasets integrated with Differential Privacy (DP) mechanisms, thereby enabling data-driven research and model training without direct exposure of sensitive information. Our approach incorporates DP-based noise injection methods, including Laplace and Gaussian distributions, into the data generation process. We then evaluate the utility of these DP-enhanced synthetic datasets by comparing the performance of ML models trained on them against models trained on the original data. To substantiate privacy guarantees, we assess the resilience of the generated synthetic data to membership inference attacks and related threats. The experimental results demonstrate that integrating DP within LLM-driven synthetic data generation offers a viable balance between privacy protection and data utility. This study provides a foundational methodology and insight into the privacy-preserving capabilities of LLMs, paving the way for compliant and effective ML research and applications.

Freight truck-related crashes pose significant challenges, leading to substantial economic losses, injuries, and fatalities, with pronounced spatial disparities across different regions. This study adopts a transport geography perspective to examine spatial justice concerns by employing deep counterfactual inference models to analyze how socioeconomic disparities, road infrastructure, and environmental conditions influence the geographical distribution and severity of freight truck crashes. By integrating road network datasets, socioeconomic attributes, and crash records from the Los Angeles metropolitan area, this research provides a nuanced spatial analysis of how different communities are disproportionately impacted. The results reveal significant spatial disparities in crash severity across areas with varying population densities, income levels, and minority populations, highlighting the pivotal role of infrastructural and environmental improvements in mitigating these disparities. The findings offer insights into targeted, location-specific policy interventions, suggesting enhancements in road infrastructure, lighting, and traffic control systems, particularly in low-income and minority-concentrated areas. This research contributes to the literature on transport geography and spatial equity by providing data-driven insights into effective measures for reducing spatial injustices associated with freight truck-related crashes.

The study aims to investigate the similarities and differences in the brain damage caused by Hypoxia-Ischemia (HI), Hypoglycemia, and Epilepsy. Hypoglycemia poses a significant challenge in improving glycemic regulation for insulin-treated patients, while HI brain disease in neonates is associated with low oxygen levels. The study examines the possibility of using a combination of medical data and Electroencephalography (EEG) measurements to predict outcomes over a two-year period. The study employs a multilevel fusion of data features to enhance the accuracy of the predictions. Therefore this paper suggests a hybridized classification model for Hypoxia-Ischemia and Hypoglycemia, Epilepsy brain injury (HCM-BI). A Support Vector Machine is applied with clinical details to define the Hypoxia-Ischemia outcomes of each infant. The newborn babies are assessed every two years again to know the neural development results. A selection of four attributes is derived from the Electroencephalography records, and SVM does not get conclusions regarding the classification of diseases. The final feature extraction of the EEG signal is optimized by the Bayesian Neural Network (BNN) to get the clear health condition of Hypoglycemia and Epilepsy patients. Through monitoring and assessing physical effects resulting from Electroencephalography, The Bayesian Neural Network (BNN) is used to extract the test samples with the most log data and to report hypoglycemia and epilepsy Keywords- Hypoxia-Ischemia , Hypoglycemia , Epilepsy , Multilevel Fusion of Data Features , Bayesian Neural Network (BNN) , Support Vector Machine (SVM)

This paper investigates Who's Harry Potter (WHP), a pioneering yet insufficiently understood method for LLM unlearning. We explore it in two steps. First, we introduce a new task of LLM targeted unlearning, where given an unlearning target (e.g., a person) and some unlearning documents, we aim to unlearn only the information about the target, rather than everything in the unlearning documents. We further argue that a successful unlearning should satisfy criteria such as not outputting gibberish, not fabricating facts about the unlearning target, and not releasing factual information under jailbreak attacks. Second, we construct a causal intervention framework for targeted unlearning, where the knowledge of the unlearning target is modeled as a confounder between LLM input and output, and the unlearning process as a deconfounding process. This framework justifies and extends WHP, deriving a simple unlearning algorithm that includes WHP as a special case. Experiments on existing and new datasets show that our approach, without explicitly optimizing for the aforementioned criteria, achieves competitive performance in all of them. Our code is available at https://github.com/UCSB-NLP-Chang/causal_unlearn.git.

The detrimental effects of air pollutants on human health have prompted increasing concerns regarding indoor air quality (IAQ). The emergence of digital health interventions and citizen science initiatives has provided new avenues for raising awareness, improving IAQ, and promoting behavioural changes. The Technology Acceptance Model (TAM) offers a theoretical framework to understand user acceptance and adoption of IAQ technology. This paper presents a case study using the COM-B model and Internet of Things (IoT) technology to design a human-centred digital visualisation platform, leading to behavioural changes and improved IAQ. The study also investigates users' acceptance and adoption of the technology, focusing on their experiences, expectations, and the impact on IAQ. Integrating IAQ sensing, digital health-related interventions, citizen science, and the TAM model offers opportunities to address IAQ challenges, enhance public health, and foster sustainable indoor environments. The analytical results show that factors such as human behaviour, indoor activities, and awareness play crucial roles in shaping IAQ.